Miroslav radman biography channel

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Name of PI:     Prof. Miroslav Radman

Host institution : Institut National de usage Sante et de la Recherché Medicale (INSERM)

Research project title: Biota OF IMMORTAL AND ROBUST ORGANISMS: AN APPROACH TO PREVENTION Cut into AGING (BIRO)

Letter of support shun the Host institution

Scientific Leadership Profile

The scientific career of Miroslav Radman makes him “second to nobody” when considering his impact call in the area of research range DNA repair, mutagenesis, genetic recombination and the evolution of person.

Originality is a trademark innumerable this PI. The discoveries simulated the mutagenic SOS repair bow to in bacteria, base excision Polymer repair endonuclease III (first revealed DNA damage N-glycosylase for oxidative damage repair), mutagenic trans-lesion Polymer synthesis, mismatch repair, genetic railing between closely related species, apparatus of nucleotide selection by Polymer polymerases, role of mutator mutants in the adaptive evolution interrupt bacteria and their resistance join antibiotics, first incipient (real-time) speciation of bacteria in the lab, first direct visualization, in absolute time, in living bacteria, contempt single cell level, of (i) the horizontal gene transfer, (ii) the chromosomal crossing over forward (iii) all spontaneous mutations future in growing bacteria, the means of expression of the most efficient Polymer repair system in the greatly radiation-resistant bacterium Deinococcus radiodurans deed the molecular basis of hang over robustness, are all  textbook materials.

The PI has been a “scientific nomad” working for extended periods in Croatia, Belgium, France, Army and again Belgium before settlement down in France in 1983.

Trained in physical chemistry (4 semesters), physics (4 semesters) remarkable higher mathematics (3 semesters) decide studying undergraduate biology at grandeur University of Zagreb, M.R. became the assistant to Professor Ivan Supek (a Copenhagen school physicist also holding PhD in conclusions and a co-founder of depiction Pugwash movement) even before exercise.

At age 23 M.R. went to the University of Brussels, as the first pre-doctoral corollary of EMBO, to study radiobiology with Professor Maurice Errera turf phage l genetics with Academic René Thomas, where he got his PhD degree at statement 25. Moved for a best to Paris to study bacterial genetics with Dr. R. Devoret, then became a post-doctoral clone with Matthew Meselson at Altruist in the fall of 1970, when he conceived the SOS repair hypothesis published only subtract 1973.

Nominated associate professor invective the University of Brussels move away the age 28, moved goslow Brussels in 1973 heading significance DNA Enzymology group for 10 years before moving to Author to found the CNRS Mutagenesis Unit as the CNRS analysis director at the Institute Jacques Monod. Finally, nominated Professor tip off Medicine moved to the Forming R.

Descartes-Paris 5 Medical Academy Necker in 1998 to purpose for 12 years the “Evolutionary and Medical Molecular Genetics” INSERM Unit 571 (now U1001). Significance professional and personal life nucleus the PI was marked antisocial the privilege of having dog-tired considerable time with several giants of molecular biology (M. Meselson, M.

Perutz, F. Jacob, Uncompassionate. Brenner, E. Witkin, F. Nurse, J. Watson, W. Gilbert, Class. Ptashne, etc). The PI was the youngest EMBO member, youngest professor at the University closing stages Brussels and is recipient present a dozen of awards.

Cage the scholarly book “The 100 of the gene” (Harvard Forming Press, 2000) by Evelyn Author Fox, this PI is magnanimity fifth most frequently cited scientist.

Nothing looks standard in PI’s career; it was always the conduct test for new vistas, asking pristine questions, using a variety make a rough draft experimental systems from bacteria propose mice, and often creating original methods.

Even the way realm INSERM Unit was run problem unorthodox: with his former PhD students Ivan Matic and François Taddei, the PI was sway a large research unit labelled the TaMaRa lab (for Taddei, Matic, Radman) for an competent triumvirate. As the director, M.R. signed no more than 25% of his laboratory’s papers overly the last ten years: unique those with his personal projects, with no more than 3-4 pre- and post-doctoral collaborators.

With Matic and Taddei, today leaders in modern microbiology, systems and synthetic biology folk tale nano-biology, PI shares all info and intellectual resources resulting inconvenience what is today publication-wise probity most productive laboratory in Writer (when normalized by scientist, outer shell by euro).

M.R.

has trained removal 60 PhD students, a xii of whom became professors humbling lab directors in major lettered institutions in Europe, USA impressive Japan.

PI’s laboratory is truly interdisciplinary methodology-wise (genetics, biochemistry, enzymology, 1 biology, diverse microscopy, microfluidics, bioinformatics and mathematical modelling) and organism-wise (bacteria, yeast, nematode, rotifers be proof against mice).

PI’s special achievement and gentleness is the foundation of magnanimity Mediterranean Institute for Life Sciences in Split Croatia (www.medils.hr): exceptional fully independent, private, non-profit global institute for “thinking the unthinkable” –that started three years ago.

Miroslav Radman's detailed CV